Ligation clip module and clip applier

ABSTRACT

A ligation clip module including a module housing that is compressible from an uncompressed condition to a compressed condition. The module housing includes a proximal portion, a distal portion, and a lumen extending therethrough. The ligation clip module further includes a pusher slidably disposed in the lumen of the module housing and a ligation clip disposed in the proximal portion of the module housing at a location distal of the pusher.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of and priority to U.S. Provisional Patent Application No. 62/414,820 filed Oct. 31, 2016, the entire disclosure of which is incorporated by reference herein.

BACKGROUND 1. Technical Field

The present disclosure generally relates to a medical instrument for use with a surgical ligation clip applier. More particularly, the present disclosure is directed to a single-fire module for housing a two-part ligation clip for securing and closing the two-part ligation clip around a vessel to be occluded.

2. Background of Related Art

Surgical procedures often require ligation (e.g., the closing off) of blood vessels to control or stop bleeding. In a laparoscopic surgical procedure, a small entrance incision is made in the skin through which a surgeon may introduce a hollow tube or access port (e.g., trocar). The access port allows the surgeon to insert a number of different surgical instruments therethrough for performing surgical procedures far removed from the incision.

During laparoscopic procedures, the termination of the flow of blood or another fluid through one or more vessels is often required. The surgeon may apply a surgical clip to the blood vessel or other duct to prevent the flow of bodily fluids therethrough. Typically, a module containing the clip is attached to the distal end of a ligation clip applier. The ligation clip applier uses a plunger or piston to fire the clip onto the vessel. Once applied to the vessel, the compressed clip terminates the flow of fluid therethrough.

Ligation clips are typically fabricated from a biocompatible material, such as metal alloys or polymers. For certain procedures, it may be advantageous to use bioabsorbable clips (e.g., instead of metal alloy or polymer clips) because they can be absorbed into the body over time, rather than remaining in the body indefinitely. Due to their unique properties, it is difficult to scale bioabsorbable ligation clips down in size while still maintaining their functionality (e.g., strength, degradation properties, and the like). In contrast, metal alloy or polymeric clips may be scaled down in size without suffering drawbacks, which allows them to fit in smaller module housings. Since a larger module housing is required for bioabsorbable clips, a larger clip applier shaft, entrance incision, and access port are also required.

Accordingly, a need exists for a module housing that can accommodate larger bioabsorbable clips and that can be used with clip appliers and access ports designed for smaller module housings and/or ligation clips.

SUMMARY

The present disclosure relates to ligation clip modules for use with endoscopic surgical clip appliers.

According to an aspect of the present disclosure, a ligation clip module is provided and includes a module housing that is compressible from an uncompressed condition to a compressed condition. The module housing includes a proximal portion and a distal portion, and a lumen extending therethrough. The ligation clip module further includes a pusher slidably disposed in the lumen of the module housing, and a ligation clip disposed in the proximal portion of the module housing at a location distal of the pusher.

The module housing may include an outer surface having a first protrusion extending therefrom and an immobilizer extending into the lumen thereof

The pusher may include a pusher body having an enlarged proximal portion and an enlarged distal portion.

The module housing may be compressed from the uncompressed condition to the compressed condition such that the first protrusion of the module housing is advanceable into an open end of a distal end of a shaft of a ligation clip applier, and such that the proximal end of the module housing is selectively connected to the distal end of the shaft of the ligation clip applier. The module housing may thus be maintained in the compressed condition.

In use, when the module housing is in the compressed condition, the immobilizer of the module housing may be disposed between the enlarged proximal portion and the enlarged distal portion of the pusher body such that the pusher is prevented from axial movement within the module housing.

In use, when the module housing is in the compressed condition and disposed in the distal end of the ligation clip applier, the enlarged proximal portion of the pusher may be engagable by an advancing mechanism of the ligation clip applier such that the enlarged proximal portion of the pusher engages the immobilizer of the module housing whereby the module is urged axially toward the distal end of the shaft of the ligation clip applier.

Also in use, when the first protrusion of the module housing is urged distally past the distal end of the shaft of the ligation clip applier, the module housing may be free to return to the uncompressed condition from the compressed condition.

The ligation clip may be a two-part ligation clip having a first part formed to be closed about a vessel and a second part moveable relative to the first part to cause the first part to close.

The ligation clip may be formed from a bioabsorbable material.

The pusher may include retaining wings disposed on the pusher body for retaining the pusher in the module housing.

The module housing may include a recess formed in the outer surface thereof for receiving a latch of the ligation clip applier, whereby the module housing may be selectively fixedly secured to the distal end of the shaft of the ligation clip applier.

According to another aspect of the present disclosure, a ligation clip module is provided for selective connection to a handle assembly of a ligation clip applier and actuatable by an advancing mechanism of the handle assembly. The ligation clip module includes a module housing that is compressible from an uncompressed condition to a compressed condition. The module housing includes an outer surface having a first protrusion extending therefrom, a proximal end being configured for selective connection to a distal end of a shaft of the ligation clip applier, a distal end, and a lumen extending therethrough and having an immobilizer extending thereinto.

The ligation clip module further includes a pusher slidably disposed in the lumen of the module housing. The pusher includes a pusher body having an enlarged proximal portion and an enlarged distal portion.

The ligation clip module also includes a ligation clip slidably disposed in the lumen of the module housing at a location distal of the pusher.

In use, the module housing is compressed from the uncompressed condition to the compressed condition such that the first protrusion of the module housing is advanceable into an open end of the distal end of the shaft of the ligation clip applier, and such that the proximal end of the module housing is selectively connected to the distal end of the shaft of the ligation clip applier, and wherein the module housing is maintained in the compressed condition.

Also in use, when the module housing is in the compressed condition, the immobilizer of the module housing is disposed between the enlarged proximal portion and the enlarged distal portion of the pusher body such that the pusher is prevented from axial movement within the module housing.

According to yet another aspect of the present disclosure, a ligation clip applier is provided and includes a handle assembly and a ligation clip module that is selectively connectable to the shaft of the handle assembly. The handle assembly includes a fixed handle, a trigger, a shaft extending from the fixed handle, and an advancing mechanism supported in the fixed handle and the shaft, the advancing mechanism being actuatable by the trigger.

The ligation clip module includes a module housing that is compressible from an uncompressed condition to a compressed condition. The module housing includes a proximal portion and a distal portion, and a lumen extending therethrough. The ligation clip module further includes a pusher slidably disposed in the lumen of the module housing, and a ligation clip disposed in the proximal portion of the module housing at a location distal of the pusher.

BRIEF DESCRIPTION OF THE DRAWINGS

Objects and features of the present disclosure will become apparent to those of ordinary skill in the art when descriptions of various embodiments thereof are read with reference to the accompanying drawings, of which:

FIG. 1 is a side elevational view of a ligation clip applier in accordance with the present disclosure;

FIG. 2 is a perspective view, with parts separated, of a handle assembly and a proximal end of a neck portion of the ligation clip applier of FIG. 1;

FIG. 3 is a perspective view of an advancing mechanism of the ligation clip applier of FIG. 1;

FIG. 4 is a cross-sectional, elevational view of the proximal end of the ligation clip applier illustrating the handle assembly in three different positions;

FIG. 5 is an exploded perspective view of a ligation clip module;

FIG. 6 is an enlarged cross-sectional, side elevational view of a distal end of a neck portion of the ligation clip applier of FIG. 1, with a loaded ligation clip module attached thereto in a compressed condition;

FIG. 7 is an enlarged cross-sectional, side elevational view of the distal end of the neck portion of the ligation clip applier of the neck portion of the ligation clip applier of FIG. 6, with a loaded clip module attached thereto in an extended condition;

FIG. 8 is an enlarged cross-sectional, side elevational view of a distal end of a neck portion of the ligation clip applier of FIG. 1, with a loaded ligation clip module, according to another embodiment of the present disclosure, attached thereto in a compressed condition;

FIG. 8A illustrates another cross-sectional view of FIG. 8;

FIG. 9 is an enlarged cross-sectional, side elevational view of the distal end of the neck portion of the ligation clip applier of the neck portion of the ligation clip applier of FIG. 8, with a loaded clip module attached thereto in an extended condition; and

FIG. 9A illustrates another cross-sectional view of FIG. 9.

DETAILED DESCRIPTION OF THE EMBODIMENTS

Embodiments of ligation clips, in accordance with the present disclosure, will now be described in detail with reference to the drawing figures wherein like reference numerals identify similar or identical structural elements. As shown in the drawings and described throughout the following description, as is traditional when referring to relative positioning on a surgical instrument, the term “proximal” refers to the end of the instrument which is closer to the user and the term “distal” refers to the end of the instrument which is further away from the user.

As shown in FIGS. 1 and 2, a ligation clip applier, in accordance with an embodiment of the present disclosure, is generally designated as 100. Ligation clip applier 100 includes a handle assembly 110, an elongated and round or cylindrical neck portion or assembly 120 projecting from or extending from handle assembly 110, and a ligation clip module 200 (FIG. 5) that can be removably and selectively mounted on a distal end of neck portion 120. As will be described in greater detail below, in operation, as handle assembly 110 is actuated, a single ligation clip 220 (FIG. 5) is fired and formed around a vessel to be ligated.

With reference to FIGS. 3 and 4, neck portion 120 includes an advancing mechanism 130 slidably disposed within hollow shaft 122 thereof. Advancing mechanism 130 includes an advancing shaft 132 that supports an actuator 134 at its distal end portion.

With reference to FIG. 4, when squeezable trigger 114 of handle assembly 110 is pivoted in the counterclockwise direction, a top or actuating end 114 a of squeezable trigger 114 engages a proximal end of the advancing shaft 132 thereby urging advancing shaft 132 distally against the biasing force of spring 136.

For a more detailed discussion of the construction and operation of ligation clip applier 100, and specifically handle assembly 110 thereof, reference may be made to U.S. Pat. No. 5,354,304, the entire content of which is incorporated herein by reference.

Referring now to FIGS. 5 and 6, ligation clip module 200 is shown in accordance with an exemplary embodiment of the present disclosure. Ligation clip module 200 includes a module housing 201, a protrusion 202 extending from an outer surface of module housing 201, a groove 203 formed in the outer surface of module housing 201, and jaws 204 extending distally from module housing 201. Module housing 201 of ligation clip module 200 includes a proximal end portion 201 a, a distal end portion 201 b and a lumen 201 c extending therethrough. Protrusion 202 of ligation clip module 200 may be any type of protuberance or plurality of protuberances, such as posts, flanges, fins, bumps, lumps, knobs, ridges, or the like. In an embodiment, protrusion 202 may be disposed radially on the outer surface of module housing 201. Groove 203 of module housing 201 may be any type of surface for receiving a pawl 126 a of a latch 126, such as an indentation, notch, slot, recess, or the like (see FIG. 6).

Ligation clip module 200 includes a pusher 210 disposed within lumen 201 c (FIGS. 5-7) of module housing 201. Pusher 210 may include a distal end 212 having an enlarged distal portion 212 a, a proximal end 213, and a pusher body 214. Pusher 210 may have retaining wings, flanges or tabs 215 (FIGS. 5-7) extending from pusher body 214, for retaining pusher 210 in module housing 201. For a detailed description of the construction and operation of wings 215 of pusher 210 of ligation clip module 200, reference may be made to U.S. Pat. No. 5,972,003, the entirety of which is incorporated herein by reference.

Ligation clip module 200 includes a ligation clip 220 disposed in lumen 201 c of module housing 201 that is releasably supported adjacent the distal end 201 b of module housing 201. Ligation clip 220 includes a U-shaped clip body 221 slidably connected to a Y-shaped clip track 222 through a post 223 located at an apex of clip track 222. To close ligation clip 220 around a vessel, clip track 222 is held stationary by post 223 as clip body 221 is moved distally toward clip track 222. This movement urges the legs of clip body 221 outwardly as they begin to close over and clamp around the arms of clip track 222. For a detailed description of the construction and operation of ligation clip 220, reference may be made to U.S. Pat. Nos. 4,590,937, 5,306,283, and 5,972,003, the entirety of each of which is incorporated herein by reference.

FIG. 6 illustrates how ligation clip module 200 is compressed, inserted, and connected to the neck portion 120 of hollow shaft 122 according to an exemplary embodiment of the present disclosure. In accordance with the present disclosure, ligation clip module 200 is compressible such that relatively larger ligation clips 220 may be inserted into hollow shafts 122 of clip appliers 100 that are designed for relatively smaller ligation clips, e.g., a ligation clip 220 designed for a 10 mm shaft clip applier and/or access port may be inserted into a 5 mm shaft clip applier and/or access port. As such, a surgeon may make an entrance incision of a relatively reduced size for an access port during laparoscopy (which is ultimately less invasive to the patient), while still possessing the versatility and/or maintaining the functionality of a relatively larger ligation clip. Ligation clip module 200 may be particularly useful with bioabsorbable clips, which, due to their material properties, may be difficult to scale down in size without reducing their effectiveness.

With continued reference to FIG. 6, to begin insertion of ligation clip module 200 into the open distal end of hollow shaft 122 of ligation clip applier 100, a surgeon may manually compress jaws 204 together such that ligation clip module 200 is moved from an uncompressed position to a compressed position, so that the overall diameter of ligation clip module 200 is reduced to a diameter smaller than an inner diameter of hollow shaft 122. In an embodiment, ligation clip module 200 may be formed from any compressible, resilient material such that ligation clip module 200 is movable from the uncompressed position to the compressed position. Compressing jaws 204 of ligation clip module 200 permits protrusion 202 to be inserted into hollow shaft 122 and into neck portion 120 of ligation clip applier 100. The inner walls of hollow shaft 122 serve to keep ligation clip module 200 in the compressed position by exerting a radial force onto ligation clip module 200 and protrusion 202.

In order to load and secure ligation clip module 200 in the neck portion 120 of hollow shaft 122 of ligation clip applier 100, a spring-loaded latch 126 is pivotably mounted in a wall of hollow shaft 122. Latch 126 has a pawl 126 a extending therefrom. The surgeon will then advance ligation clip module 200 in the direction of arrow “A” (FIGS. 6 and 7) until pawl 126 a of latch 126 catches within groove 203 of module housing 201 of ligation clip module 200 such that ligation clip module 200 is securely locked in neck portion 120. As will be described in greater detail below, groove 203 of module housing 201 is dimensioned such that ligation clip module 200 may move axially within hollow shaft 122 of ligation clip applier 100, and have its axial movement limited by pawl 126 a of latch 126.

As so loaded, ligation clip module 200 remains in the compressed position. At least a portion of ligation clip module 200 may remain outside the open distal end of hollow shaft 122, such as, for example, the portion of ligation clip module 200 distal of protrusion 202. Alternatively (not shown), while in the compressed position, the entire ligation clip module 200 may be inserted within the neck portion 120 of hollow shaft 122 of ligation clip applier 100.

While ligation clip module 200 is inserted into neck portion 120 of hollow shaft 122 and in the compressed position (FIG. 6), an immobilizer 205 extending into lumen 201 c of module housing 201 is disposed on pusher body 214 of pusher 210, such that axial movement of pusher 210 through module housing 201 is restricted. In this position, ligation clip module 200 together with clip applier 100 may be advanced down an access port and into a patient's body. In embodiments, immobilizer 205 of ligation clip module 200 may be any type of surface disposed on or extending inwardly from an inner surface of module housing 201, such as a protrusion or protuberance.

In order to prepare ligation clip applier 100, together with loaded ligation clip module 200 for use and firing, a surgeon will partially squeeze or actuate trigger 114 of handle assembly 110 such that advancing shaft 132 abuts the proximal end 213 of pusher 210. Since immobilizer 205 of module housing 201 has restricted the movement of pusher 210, the entire ligation clip module 200 will be advanced distally forward in direction “B” of neck portion 120, as shown in FIG. 6. As ligation clip module 200 continues to be advanced distally, protrusion 202 will ultimately clear and snap over the open distal end of hollow shaft 122 such that jaws 204 are free to resiliently flex radially outward to the uncompressed position, as shown in FIG. 7. Distal advancement of ligation clip module 200 will stop when pawl 126 a of latch 126 abuts against a shoulder 203 b of groove 203. Accordingly, any further distal advancement of advancing shaft 132 will distally advance pusher 210 of ligation clip module 200 relative to module housing 201 of ligation clip module 200. Additionally, with protrusion 202 of ligation clip module 200 disposed distally of and/or in abutment with rim 122 a of hollow shaft 122, ligation clip module 200 is prevented from proximal axial movement, in direction “A,” into neck portion 120 of hollow shaft 122.

Additionally, pawl 126 a of latch 126 enters into groove 203 of ligation clip module 200, whereby ligation clip module 200 is prevented from advancing forward in direction “B.” In this position, and with reference to FIG. 7, ligation clip module 200 is uncompressed and fully secured within neck portion 120 of hollow shaft 122, and is ready for use in a firing configuration of clip applier 100. In an embodiment, a surgeon may be provided with auditory (i.e., a “snap” or “click”) or tactile feedback to indicate that protrusion 202 has advanced past the open distal end of hollow shaft 122 and that pawl 126 a of latch 126 is disposed within groove 203 of ligation clip module 200.

In this firing configuration, jaws 204 of ligation clip module 200 may be used to manipulate tissue when positioning ligation clip 220 about a vessel to be ligated. When ligation clip module 200 is in the uncompressed position, immobilizer 205 of module housing 201 has disengaged from pusher body 214, such that pusher 210 is no longer restrained by immobilizer 205. Once the desired vessel (not shown) has been located and inserted between jaws 204 of ligation clip module 200, the surgeon may then partially squeeze trigger 114 such that advancing shaft 132 of ligation clip applier 100 abuts proximal end 213 of pusher 210 of ligation clip module 200. In addition, distal end 212 of pusher 210 abuts with the proximal end of U-shaped clip body 221 of ligation clip 220, such that pusher 210 may be advanced distally to expel ligation clip 220 from ligation clip module 200, and clamp ligation clip 220 onto the vessel.

As trigger 114 is fully actuated, pusher 210 will advance U-shaped clip body 221 of ligation clip 220 distally over Y-shaped clip track 222 thereof, such that ligation clip 220 may be fully formed over the vessel. Following formation of ligation clip 220, trigger 114 is released, whereby return spring 136 is free to expand and thus withdraw advancing shaft 132 of neck portion 120. Ligation clip applier 100 along with ligation clip module 200 may be pulled back or withdrawn through the access port. The access port will cause jaws 204 and ligation module 220 to compress passively through the retracting motion. Pawl 126 a of latch 126 will prevent ligation module 200 from prematurely or unintentionally detaching from hollow shaft 122 and neck portion 120.

Following removal of ligation clip applier 100 and ligation clip module 200 from a patient's body, latch 126 may be actuated to raise and disengage pawl 126 a thereof from groove 203 of ligation clip module 200 to permit disconnection of spent ligation clip module 200 from hollow shaft 122 and neck portion 120.

A new ligation clip module 200 can then be inserted and secured in neck portion 120 of hollow shaft 122 (in the manner described above), and ligation clip applier 100 is once again ready to fire another ligation clip 220. Ligation clips 220 may be contained in kit form containing a plurality of clips, such as, for example, six (6) clips of the like. Kits may be loaded with a full set of metal clips (e.g., titanium, stainless steel or metal alloys), a full set of polymer clips (e.g., biocompatible or bioabsorbable), or a combination thereof.

In an alternative embodiment, as shown in FIGS. 8, 8A, 9 and 9A, a ligation clip module 300 may be loaded into neck portion 120 of hollow shaft 122 of ligation clip applier 100 while in a rest or uncompressed position. During loading of ligation clip module 300 in ligation clip applier 100, as ligation clip module 300 is pushed proximally in direction “A” within neck portion 120 of hollow shaft 122, a pin 127 disposed within hollow shaft 122 will engage a detent 301 disposed on an outer surface of ligation clip module 300. Detent 301 of ligation clip module 300 serves to prevent ligation clip module from being pushed further proximally within hollow shaft 122.

In this position, once loaded, a surgeon may partially squeeze trigger 114, which urges advancing shaft 132 distally and engages a proximal end of pusher 310. Bumps 302, disposed within ligation clip module 300, will abut a distal end 311 of pusher 310 and prevent pusher 310 from advancing further distally in direction “B” relative to ligation clip module 300. Likewise, retaining wings 312 will prevent pusher 310 from advancing further proximally in direction “A” relative to ligation clip module 300. Upon the partial actuation of trigger 114, the entire ligation clip module 300 will be advanced distally until stop 303 of ligation clip module 300 engages pawl 126 a of latch 126 (FIG. 9) and prevents further distal movement of ligation clip module 300 within neck portion 120 of hollow shaft 122. Additionally, boss 304 is now in engagement with rim 122 a of hollow shaft 122 FIG. 9A), which prevents accidental proximal or backward movement of ligation clip module 300 in direction “A” within neck portion 120 of hollow shaft 122. With ligation clip module 300 secured in place, a full actuation or squeeze of trigger 114 will cause distal end 311 of pusher 310 to overcome bumps 302 and engage and expel ligation clip 320 from neck portion 120 of hollow shaft 122.

Although specific embodiments of the present disclosure have been described above in detail, it will be understood that this description is merely for purposes of illustration. Various modifications of and equivalent structures corresponding to the disclosed aspects of the preferred embodiments in addition to those described above may be made by those skilled in the art without departing from the spirit of the present disclosure which is defined in the following claims, the scope of which is to be accorded the broadest interpretation so as to encompass such modifications and equivalent structures. 

What is claimed is:
 1. A ligation clip module, comprising: a module housing compressible from an uncompressed condition to a compressed condition, the module housing including: a proximal portion and a distal portion; and a lumen extending therethrough; a pusher slidably disposed in the lumen of the module housing; and a ligation clip disposed in the proximal portion of the module housing at a location distal of the pusher.
 2. The ligation clip module according to claim 1, wherein the module housing includes: an outer surface having a first protrusion extending therefrom; and an immobilizer extending into the lumen thereof.
 3. The ligation clip module according to claim 2, wherein the pusher includes a pusher body having an enlarged proximal portion and an enlarged distal portion.
 4. The ligation clip module according to claim 3, wherein the module housing is compressed from the uncompressed condition to the compressed condition such that the first protrusion of the module housing is advanceable into an open end of a distal end of a shaft of a ligation clip applier, and such that the proximal end of the module housing is selectively connected to the distal end of the shaft of the ligation clip applier, and wherein the module housing is maintained in the compressed condition.
 5. The ligation clip module according to claim 4, wherein, when the module housing is in the compressed condition, the immobilizer of the module housing is disposed between the enlarged proximal portion and the enlarged distal portion of the pusher body such that the pusher is prevented from axial movement within the module housing.
 6. The ligation clip module according to claim 5, wherein, when the module housing is in the compressed condition and disposed in the distal end of the shaft of the ligation clip applier, the enlarged proximal portion of the pusher is engagable by an advancing mechanism of the ligation clip applier such that the enlarged proximal portion of the pusher engages the immobilizer of the module housing whereby the module is urged axially toward the distal end of the shaft of the ligation clip applier.
 7. The ligation clip module according to claim 5, wherein when the first protrusion of the module housing is urged distally past the distal end of the shaft of the ligation clip applier, the module housing is free to return to the uncompressed condition from the compressed condition.
 8. The ligation clip module according to claim 1, wherein the ligation clip is a two-part ligation clip having a first part formed to be closed about a vessel and a second part moveable relative to the first part to cause the first part to close.
 9. The ligation clip module according to claim 1, wherein the ligation clip is formed from a bioabsorbable material.
 10. The ligation clip module according to claim 1, wherein the pusher includes retaining wings disposed on the pusher body for retaining the pusher in the module housing.
 11. The ligation clip module according to claim 5, wherein the module housing includes a recess formed in the outer surface thereof for receiving a latch of the ligation clip applier, whereby the module housing is selectively fixedly secured to the distal end of the shaft of the ligation clip applier.
 12. A ligation clip module for selective connection to a handle assembly of a ligation clip applier and actuatable by an advancing mechanism of the handle assembly, the ligation clip module comprising: a module housing compressible from an uncompressed condition to a compressed condition, the module housing including: an outer surface having a first protrusion extending therefrom; a proximal end being configured for selective connection to a distal end of a shaft of the ligation clip applier; a distal end; and a lumen extending therethrough and having an immobilizer extending thereinto; a pusher slidably disposed in the lumen of the module housing, the pusher including a pusher body having an enlarged proximal portion and an enlarged distal portion; and a ligation clip slidably disposed in the lumen of the module housing at a location distal of the pusher; wherein the module housing is compressed from the uncompressed condition to the compressed condition such that the first protrusion of the module housing is advanceable into an open end of the distal end of the shaft of the ligation clip applier, and such that the proximal end of the module housing is selectively connected to the distal end of the shaft of the ligation clip applier, and wherein the module housing is maintained in the compressed condition; and wherein, when the module housing is in the compressed condition, the immobilizer of the module housing is disposed between the enlarged proximal portion and the enlarged distal portion of the pusher body such that the pusher is prevented from axial movement within the module housing.
 13. The ligation clip module according to claim 12, wherein, when the module is in the compressed condition and disposed in the distal end of the shaft of the ligation clip applier, the enlarged proximal portion of the pusher is engagable by the advancing mechanism of the handle assembly of the ligation clip applier such that the enlarged proximal portion of the pusher engages the immobilizer of the module housing whereby the module is urged axially toward the distal end of the shaft of the ligation clip applier.
 14. The ligation clip module according to claim 12, wherein when the first protrusion of the module housing is urged distally past the distal end of the shaft of the ligation clip applier, the module housing is free to return to the uncompressed condition.
 15. The ligation clip module according to claim 12, wherein the ligation clip is a two-part ligation clip having a first part formed to be closed about a vessel and a second part moveable relative to the first part to cause the first part to close.
 16. The ligation clip module according to claim 12, wherein the ligation clip is formed from a bioabsorbable material.
 17. The ligation clip module according to claim 12, wherein the pusher includes retaining wings disposed on the pusher body for retaining the pusher in the module housing.
 18. The ligation clip module according to claim 12, wherein the module housing includes a recess formed in the outer surface thereof for receiving a latch of the ligation clip applier, whereby the module housing is selectively fixedly secured to the distal end of the shaft of the ligation clip applier.
 19. A ligation clip applier, comprising: a handle assembly, including: a fixed handle; a trigger; a shaft extending from the fixed handle; and an advancing mechanism supported in the fixed handle and the shaft, the advancing mechanism being actuatable by the trigger; and a ligation clip module selectively connectable to the shaft of the handle assembly, the ligation clip module including: a module housing compressible from an uncompressed condition to a compressed condition, the module housing including: a proximal portion and a distal portion; and a lumen extending therethrough; a pusher slidably disposed in the lumen of the module housing; and a ligation clip disposed in the proximal portion of the module housing at a location distal of the pusher.
 20. The ligation clip applier according to claim 19, wherein the module housing of the ligation clip module includes: an outer surface having a first protrusion extending therefrom; and an immobilizer extending into the lumen thereof.
 21. The ligation clip applier according to claim 20, wherein the pusher of the ligation clip module includes a pusher body having an enlarged proximal portion and an enlarged distal portion.
 22. The ligation clip applier according to claim 21, wherein the module housing of the ligation clip module is compressed from the uncompressed condition to the compressed condition such that the first protrusion of the module housing is advanceable into an open end of a distal end of the shaft of the handle assembly, and such that the proximal end of the module housing is selectively connected to the distal end of the shaft of the handle assembly, and wherein the module housing is maintained in the compressed condition.
 23. The ligation clip applier according to claim 22, wherein, when the module housing of the ligation clip module is in the compressed condition, the immobilizer of the module housing is disposed between the enlarged proximal portion and the enlarged distal portion of the pusher body such that the pusher is prevented from axial movement within the module housing.
 24. The ligation clip applier according to claim 23, wherein, when the module housing of the ligation clip module is in the compressed condition and disposed in the distal end of the shaft of the handle assembly, the enlarged proximal portion of the pusher is engagable by the advancing mechanism of the handle assembly such that the enlarged proximal portion of the pusher engages the immobilizer of the module housing whereby the module is urged axially toward the distal end of the shaft of the handle assembly.
 25. The ligation clip applier according to claim 23, wherein when the first protrusion of the module housing of the ligation clip module is urged distally past the distal end of the shaft of the handle assembly, the module housing is free to return to the uncompressed condition from the compressed condition.
 26. The ligation clip applier according to claim 23, wherein the module housing of the ligation clip module includes a recess formed in the outer surface thereof for receiving a latch of the handle assembly, whereby the module housing is selectively fixedly secured to the distal end of the shaft of the handle assembly. 